The skin is an uncommon site for distant metastases (with a frequency ranging from 0.7% to 10.4%, depending on the series), which most commonly occur after the identification of a primary cancer [1, 2]. More than 60 percent of skin metastases are adenocarcinomas, usually arising in the breast, lung, or large intestine [3]. In males, primary solid tumors that most often metastasize to the skin are carcinomas of the lung (24%), carcinomas of the colon (19%), and melanomas (13%). In women, breast cancer is the most frequent (69%), followed by colon cancer (9%) and melanoma (5%) [3, 4]. Gastric cancer has been reported in only 6 percent of all skin metastases in males and 1 percent in females [2].
According to Schwartz et al. cutaneous metastatic disease as the presenting sign of internal cancer is most common with cancer of the lung, kidney, and ovary [3]. Nevertheless, in a recent review, cutaneous metastases have been seen as an initial sign of cancer in 20 of 92 cases (22%) [5].
cutaneous metastases from cholangiocarcinoma are extremely rare ;p only case reports
and also should be applied for CBD cancer ;p
